5-MeO-DMT – exploring the science, history and phenomenology of this fascinating compound

Datum: 26.1. 2023, 18:30 – 21:00

Místo: Na louži 7, Ze – mě, Praha



The Czech Psychedelic Society invites you to the lecture that will dive deep into the history and science behind 5-methoxy-dimethyltryptamine (5-MeO-DMT), a naturally occurring tryptamine psychedelic found in a variety of plants and most notably toad Incilius (formerly Bufo) alvarius. Plants containing 5-MeO-DMT have been used throughout history for ritual and spiritual purposes. Currently there is a growing recreational/spiritual use of both synthetic 5-MeO-DMT, as well as toad ‘venom’, and several clinical studies are underway to study this fascinating molecule. 5-MeO-DMT is a classic serotonergic psychedelic, and is chemically similar to another short-lasting tryptamine, DMT. However, despite the similarities in the intensity and the duration of the experience, subjective effects are markedly different. Yet clinical research and understanding of the mechanisms of action of this entheogen are just beginning. In fact, so far only one clinical trial in healthy volunteers has been published, indicating the safety of up to 18mg of vapourised 5-MeO-DMT.

In this talk the current state of knowledge on 5-MeO-DMT will be summarized, covering pharmacokinetics, pharmacodynamics, and epidemiological research of recreational/spiritual use. Later on, the ongoing clinical research will be reviewed into this compound’s fascinating properties and potential therapeutic applications.

Anya Ermakova, PhD
Anya is interested in nature conservation, ethnobotany, neuroscience and psychiatry, interweaving these diverse paths through psychedelic science. Deep love for nature motivated Anya to study biology at the University of Edinburgh, while a quest to understand altered states of consciousness prompted her to complete PhD in psychiatry at Cambridge. Anya worked at the forefront of psychedelic science, starting in 2015 as a science officer for the Beckley Foundation. She then decided to pursue her passion for nature, researching peyote ecology and conservation at Imperial College London. Anya is a board member of the Chacruna Institute and a research consultant currently working on the clinical trials of 5-MeO-DMT. She is particularly interested in the phenomenology of 5-MeO-DMT experiences.


Malin Uthaug: The Effects of 5-MeO-DMT and Bufo Alvarius

English below

MALIN UTHAUG, PhD candidate: The Effects of 5-MeO-DMT and Bufo Alvarius

14.11. 2018, 19:00 – 20:30
Prostor 39, Řehořova 39, Prague



V další z cyklu přednášek České psychedelické společnosti vystoupí výzkumnice Malin Uthaug, která se ve své disertační práci věnuje tématice 5-MeO-DMT a ropuše Bufo Alvarius. Ve své přednášce představí výsledky výzkumu zaměřeného na efekty bufotoxinů na mentální zdraví, bude mluvit o terapeutickém potenciálu 5-MeO-DMT, důsledcích zvýšené konzumace tzv. „ropuší medicíny“ (the toad) a rizicích spojených s užíváním.
Přednáška proběhne v angličtině.

The Effects of 5-MeO-DMT and Bufo Alvarius
5-methoxydimethyltryptamine (5-MeO-DMT) is a fast-acting, and potent psychotropic substance which can be found in the secretions from the parotid glands of the Colorado River toad Bufo Alvarius. Recently, smoking toad secretions has become popular in various ritual settings, thus research is highly warranted to investigate the potential therapeutic impact of 5-MeO-MT in humans. This talk will summarize the first research conducted on the effects of bufotoxins on mental health. Moreover, it will highlight the consequences the consumption of “toad-medicine” has on the Bufo Alvarius toad, and the dangers of malpractice.

Malin Vedøy Uthaug is a PhD candidate at the University of Maastricht, Department of Neuropsychology & Psychopharmacology. She has a background in health and social psychology and is known for her field-work researching the effects of psychedelics, such as ayahuasca, 5-MeO-DMT and Mescaline, on mental health. She is also interested in the ethical and ecological implications of the consumption of these substances, and is highly motivated to de-stigmatize psychedelics, possibly also legalize them, and to create a scientific framework for healing trauma utilizing psychedelics.

On the side of being a student and researcher, she is a life coach and public speaker. She started her coaching project titled “Love & Gratitude” in September 2016 which serves as a platform to spread information related to positive psychology, and transpersonal psychology. Love & Gratitude has also become a way to bring about information about psychedelics, and help destigmatizing them. She has since September 2016 delivered talks, webinars and workshops in several countries world-wide.